Ep 25 – Diamorphine
Diamorphine pharmacology for the FRCA Primary: mechanism of action at mu opioid receptors, pro-drug metabolism to 6-O-acetylmorphine, neuraxial use, and M6G accumulation in renal failure.
29 May 2025
Opioids
7 episodes
Ep 25 – Oxycodone for the FRCA Primary
Oxycodone: semi-synthetic opioid, 60–87 % oral bioavailability, CYP3A4/2D6 metabolism, and equipotency conversions for FRCA Primary pharmacology.
22 May 2025
Ep 24 – Methadone for the FRCA Primary
Methadone pharmacology for FRCA Primary: µ-opioid agonist, NMDA antagonist, CYP3A4/2D6 metabolism, QT prolongation, and opioid substitution therapy.
10 May 2025
Ep 23 – Tramadol for the FRCA Primary Exam
Tramadol pharmacology for the FRCA Primary: multimodal mechanism (mu-opioid, noradrenaline, serotonin), CYP2D6 metabolism, active metabolite, serotonin syndrome.
7 May 2025
Ep.22 – Alfentanil for the FRCA Primary
Alfentanil is a short-acting μ-opioid receptor agonist used in RSI, ICU sedation, and acute analgesia — FRCA Primary pharmacology examined in full.
28 Apr 2025
Ep 15 – Morphine for the FRCA Primary Exam
Morphine for the FRCA Primary: mu-opioid receptor mechanism, pharmacokinetics, M3G/M6G metabolites, and intrathecal delayed respiratory depression.
22 Nov 2024
Ep 3 – Fentanyl For The FRCA Primary
Fentanyl pharmacology for FRCA Primary: mu-opioid receptor mechanism, pharmacokinetics, opioid receptor subtypes (MOP/DOP/KOP/NOP), and clinical dosing.
8 Nov 2024