Opioids

7 episodes

EduCastOpioidsPharmacologyPodcast

Ep 25 – Diamorphine

Diamorphine pharmacology for the FRCA Primary: mechanism of action at opioid receptors, pro-drug metabolism to 6-O-acetylmorphine and morphine, neuraxial use, and key side effects.

29 May 2025

EduCastOpioidsPharmacologyPodcast

Ep 25 – Oxycodone for the FRCA Primary

Oxycodone: semi-synthetic opioid, 60–87 % oral bioavailability, CYP3A4/2D6 metabolism, and equipotency conversions for FRCA Primary pharmacology.

22 May 2025

EduCastOpioidsPharmacologyPodcast

Ep 24 – Methadone for the FRCA Primary

Methadone pharmacology for FRCA Primary: µ-opioid agonist, NMDA antagonist, CYP3A4/2D6 metabolism, QT prolongation, and opioid substitution therapy.

10 May 2025

EduCastOpioidsPharmacologyPodcast

Ep 23 – Tramadol for the FRCA Primary Exam

Tramadol pharmacology for the FRCA Primary: multimodal mechanism (mu-opioid, noradrenaline, serotonin), CYP2D6 metabolism, active metabolite, serotonin syndrome risk.

7 May 2025

EduCastOpioidsPharmacologyPodcast

Ep.22 – Alfentanil for the FRCA Primary

Alfentanil is a short-acting μ-opioid receptor agonist used in RSI, ICU sedation, and acute analgesia — FRCA Primary pharmacology examined in full.

28 Apr 2025

EduCastOpioidsPharmacologyPodcast

Ep 15 – Morphine for the FRCA Primary Exam

Morphine for the FRCA Primary: mu-opioid receptor mechanism, pharmacokinetics, M3G/M6G metabolites, and intrathecal delayed respiratory depression.

22 Nov 2024

EduCastOpioidsPharmacologyPodcast

Ep 3 – Fentanyl For The FRCA Primary

Fentanyl pharmacology for FRCA Primary: mu-opioid receptor mechanism, pharmacokinetics, opioid receptor subtypes (MOP/DOP/KOP/NOP), and clinical dosing.

8 Nov 2024