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Anaesthetic Science — Straight Into Your Ears, Twice A Month!

  • We want you to gain the knowledge easily, so you can learn the tricky bit of actually anaesthetising in the hospital
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  • Pharmacology — exploring almost all anaesthetic drugs and their use
  • Explainers on TCI, compartmental pharmacokinetics, and related critical concepts
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anti cholinesterases
EduCastPharmacologyPodcast

AntiCholinesterases For The Anaesthetically Adept

Introduction Anticholinesterases. You think you know what you’re getting into: neostigmine, reversal, done. Then you realise it can go considerably further than that. Nerve agents. Myasthenia gravis. Alzheimer’s disease + classification based on where exactly a drug binds to an enzyme th

19 Apr 2026

sugamamdex_banner
EduCastPharmacologyPodcast

Sugammadex For Anaesthetists

Introduction Sugammadex changed the game for neuromuscular blockade reversal. Before it came along, your only option for reversing a non-depolarising block was neostigmine, which meant waiting until the block was shallow enough, co-administering glycopyrrolate or atropine to manage the cholinergic s

1 Apr 2026

pancuronium
EduCastPharmacologyPodcast

Pancuronium For Anaesthetists

Introduction Pancuronium bromide is the original aminosteroid neuromuscular blocking agent arriving in clinical practice in the late 1960s and paved the way for every aminosteroid that followed. While it has been superseded by rocuronium and vecuronium in modern anaesthetic practice, understanding p

22 Mar 2026

Vecuronium
EduCastPharmacologyPodcast

Vecuronium For Anaesthetists

Introduction Vecuronium Pharmacology Vecuronium Physico-Chemical properties Name Vecuronium (Brand name Norcuron) Class A mono-quartenary aminosteroid Chemical Make Up The mono-quaternary analogue of pancuronium History Synthesised by Savage and Coaworks at the Organon research laboratories, in the

26 Feb 2026

cis atracurium
EduCastPharmacologyPodcast

Cisatracurium For Anaesthetists

Introduction Cisatracurium is one of the ten isomers found in Atracurium, and it has been selected out as a useful, potent, predictably degrading drug with a very stable side effect profile! Althought, it might be that, whilst Cisatracurium probably sounded like a great idea at the time… it wa

18 Feb 2026

Mivacurium for anaesthetists
EduCastPharmacologyPodcast

Mivacurium For Anaesthetists

Introduction Mivacurium is a non-depolarising neuromuscular blocking agent of the bis-benzylisoquinolinium class, with a unique metabolism by plasma cholinesterase considering it is a non-depolarising muscle relaxant. Developed to provide more stable cardiovascular side effect profiles than its

1 Feb 2026

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Opioids: Almost Everything You Need to Know

A deep-dive into opioid pharmacology for the Primary FRCA — mechanisms, PK/PD, and clinical use.

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Local Anaesthetics: Everything Your Brain Needs to Know

Mechanisms, structure, and clinical pharmacology of all LA drugs.

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Hypnotica: All of the Induction Drugs

Propofol, ketamine, thiopentone, etomidate — complete PK/PD and exam-ready.

Chapter Series

Comparing Volatile Anaesthetic Agents

Side-by-side pharmacology of sevoflurane, desflurane, and isoflurane.

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